Accounting for Time: Circadian Rhythms in the Time of COVID-19

J Biol Rhythms. 2021 Feb;36(1):4-8. doi: 10.1177/0748730420953335. Epub 2020 Sep 2.

Abstract

The COVID-19 pandemic has necessitated novel approaches and collaborative efforts across multiple disciplines. It is known that various aspects of our physiology and response to pathogens are under tight clock control. However, the assimilation of circadian biology into our clinical and research practices is still evolving. Using a focused review of the literature and original analyses of the UK Biobank, we discuss how circadian biology may inform our diagnostic and therapeutic strategies in this pandemic.

Keywords: COVID-19; chronotherapy; circadian; immunity; translational medicine; vaccines.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • COVID-19 / epidemiology
  • COVID-19 / prevention & control*
  • COVID-19 / virology
  • Circadian Clocks / physiology*
  • Circadian Rhythm / physiology*
  • Female
  • Humans
  • Male
  • Models, Biological
  • Pandemics
  • SARS-CoV-2 / isolation & purification*
  • SARS-CoV-2 / physiology
  • Time Factors