We studied 400 patients with ischemic stroke, including 200 patients (the main group), who received 3 courses of phenotropil in the complex rehabilitation treatment in dosage 400 mg/day during 1 year after stroke. The extent of restoration of neurologic functions and daily living activities was assessed with Barthel, Lindmark, Scandinavian scales and Merton and Sutton scale. The restoration of neurologic and daily living activities was significantly (p < 0.0001) better in the main group compared to the control one.